To dispose of biomedical waste properly, follow these five steps: (1) Identify and segregate waste immediately at the point of generation using color-coded containers, (2) Use FDA-cleared puncture-resistant sharps containers and leak-proof biohazard bags, (3) Store waste securely away from public areas for no more than 7 days at room temperature, (4) Schedule pickup with a licensed medical waste hauler, and (5) Maintain manifest documentation proving proper disposal. This process ensures compliance with OSHA, EPA, and state regulations while protecting public health.
Step-by-Step Biomedical Waste Disposal Guide
Whether you’re a healthcare facility, dental office, veterinary clinic, or home healthcare provider, proper biomedical waste disposal follows the same fundamental steps.
Step 1: Identify Your Biomedical Waste
Before you can dispose of waste properly, you must identify what qualifies as biomedical waste.
Ask These Questions:
Is it contaminated with blood or body fluids?
- If YES → Biomedical waste
- If NO → May be regular trash
Does it contain infectious agents?
- If YES → Biomedical waste
- If NO → Check other criteria
Is it a sharp object that could cause injury?
- If YES → Sharps waste (biomedical)
- If NO → Check other criteria
Is it pharmaceutical waste?
- If YES → Biomedical waste (special handling)
- If NO → May be regular trash
Common Biomedical Waste Items:
Sharps:
- Needles and syringes
- Lancets
- Scalpels and surgical blades
- Broken glass contaminated with blood
- Suture needles
Contaminated Materials:
- Blood-soaked bandages and gauze
- Used gloves from patient contact
- Contaminated PPE (masks, gowns, face shields)
- Specimen swabs
- Contaminated lab materials
Pathological Waste:
- Tissues and organs
- Body parts
- Surgical specimens
- Extracted teeth
- Biopsy samples
Pharmaceutical Waste:
- Expired medications
- Chemotherapy drugs
- Contaminated medication vials
- Controlled substances
Real-World Example:
A medical assistant draws blood from a patient. The needle and syringe = sharps waste. The alcohol prep pad = regular trash (not contaminated). The used gloves = biomedical waste if they touched blood, regular trash if they only touched the patient’s arm. The bandage = biomedical waste if blood-soaked, regular trash if dry.
Step 2: Segregate Waste Immediately
The moment waste is generated, place it in the correct container. Never let biomedical waste touch regular trash.
Color-Coded Container System:
Red Containers/Bags: Infectious Waste
Use for:
- Contaminated bandages and gauze
- Blood-soaked materials
- Used gloves from patient care
- Contaminated PPE
- Specimen containers
Container requirements:
- Rigid or heavy-duty plastic bags
- Labeled with biohazard symbol
- Leak-proof construction
- Closeable/sealable
White/Yellow Containers: Sharps
Use for:
- All needles and syringes
- Lancets and phlebotomy equipment
- Scalpels and blades
- Broken glass with blood
- Any sharp object that could puncture skin
Container requirements:
- FDA-cleared puncture-resistant
- Rigid plastic construction
- One-way opening (can’t reach in)
- Clearly labeled “SHARPS”
- Never more than 3/4 full
Black/Blue Bags: Pharmaceutical Waste
Use for:
- Expired medications
- Unused pharmaceuticals
- Contaminated medication containers
- Chemotherapy waste (separate from other pharmaceutical)
Container requirements:
- Leak-proof bags or containers
- Labeled “PHARMACEUTICAL WASTE”
- Locked storage if controlled substances
- Separate containers for chemotherapy
Yellow Bags: Pathological Waste
Use for:
- Tissues and organs
- Body parts
- Surgical specimens
- Extracted teeth
Container requirements:
- Leak-proof construction
- Labeled “PATHOLOGICAL WASTE”
- Refrigerated if stored more than 48 hours
Segregation Best Practices:
DO:
- Segregate at the point of generation
- Use the right container for each waste type
- Close containers immediately after use
- Keep containers within arm’s reach
- Replace containers when 3/4 full
DON’T:
- Mix waste types in one container
- Overfill containers
- Reach into sharps containers
- Leave containers open
- Store containers in patient areas longer than necessary
Real-World Example:
A dental office has three containers in each operatory: (1) red bag for contaminated gauze and gloves, (2) sharps container for needles and blades, (3) regular trash for uncontaminated items like paper towels. The assistant segregates waste immediately after each procedure.
Step 3: Use Proper Containers
Container selection is critical for safety and compliance.
Sharps Containers:
Requirements:
- FDA-cleared (look for FDA clearance on label)
- Puncture-resistant (rigid plastic, not cardboard)
- Leak-proof base and sides
- Secure lid that locks when full
- Biohazard symbol and “SHARPS” label
- Available sizes: 1-quart to 18-gallon
Where to Place:
- Within arm’s reach of where sharps are used
- Mounted on wall or placed on stable surface
- Never on floor
- Away from public access
- In every room where sharps are used
When to Replace:
- When 3/4 full (NEVER fill to the top)
- When fill line is reached
- When container is damaged
- According to your disposal schedule
Cost:
- Small (1-quart): $3-$8 each
- Medium (2-3 gallon): $8-$15 each
- Large (8-18 gallon): $20-$40 each
Biohazard Bags:
Requirements:
- Red or orange color (some states allow clear with red label)
- Biohazard symbol printed on bag
- Tear-resistant (minimum 2 mil thickness)
- Leak-proof construction
- Closeable (tie, zip, or seal)
Sizes:
- Small (6-8 gallon): For exam rooms, dental offices
- Medium (20-30 gallon): For hospital rooms, clinics
- Large (40-50 gallon): For central collection, storage areas
Cost:
- Small bags: $0.15-$0.40 each
- Medium bags: $0.30-$0.75 each
- Large bags: $0.50-$1.50 each
Rigid Containers (for pathological/pharmaceutical):
Requirements:
- Leak-proof construction
- Secure lids
- Labeled with waste type
- Appropriate size for volume generated
Real-World Example:
A physician office uses 2-gallon sharps containers in each exam room ($10 each), 10-gallon red biohazard bags in each room ($0.50 each), and one 5-gallon pharmaceutical waste container in the medication room ($25). Total container cost per month: approximately $150 for all containers.
Step 4: Store Waste Securely
Once containers are full, they must be stored properly until pickup.
Storage Requirements:
Location:
- Separate from patient care areas
- Separate from food preparation/storage
- Away from public access
- Secured area (locked if possible)
- Well-ventilated
Environmental Controls:
- Room temperature: Maximum 7 days storage
- Refrigerated (below 40°F): Maximum 30 days storage
- Pathological waste: Refrigerate if stored more than 48 hours
Safety Measures:
- Containers on shelves or pallets (not on floor)
- Spill containment materials available
- Fire extinguisher nearby
- Biohazard signage on door
- Emergency contact information posted
Documentation:
- Log when containers moved to storage
- Track storage duration
- Note when containers leave for pickup
Storage Area Setup:
Small Office (1-2 providers):
- Dedicated closet or small room
- 25-50 square feet
- Wall-mounted shelving
- Single door with lock
- Biohazard sign on door
Medium Clinic (5-10 providers):
- Dedicated room
- 100-200 square feet
- Multiple shelving units
- Separate areas for different waste types
- Refrigerator for pathological waste
- Eyewash station
Large Facility (Hospital, large clinic):
- Multiple storage areas throughout facility
- Central storage with refrigeration
- 500+ square feet
- Climate control
- Security cameras
- Access control system
Real-World Example:
A 3-provider medical office converts a 50-square-foot storage closet into a medical waste storage area. They install wall-mounted shelves, add a biohazard sign to the door, install a lock, and place spill cleanup materials inside. Cost: $300 for materials and setup.
Step 5: Schedule Licensed Hauler Pickup
You cannot dispose of biomedical waste in regular trash. You must use a licensed medical waste hauler.
Finding a Licensed Hauler:
Verify Credentials:
- State medical waste transporter license
- DOT hazardous materials permit
- EPA ID number (if applicable)
- Insurance certificate (minimum $1 million)
- References from similar facilities
Questions to Ask:
- What’s your pickup schedule?
- What treatment methods do you use?
- Where is your treatment facility located?
- Do you provide containers?
- What documentation do you provide?
- What’s your emergency pickup availability?
Pickup Frequency Options:
Weekly Pickup (Most Common):
- Best for: Small to medium offices
- Volume: 10-50 pounds per week
- Cost: $100-$300 per month
Bi-Weekly Pickup:
- Best for: Very small offices, low volume
- Volume: 5-20 pounds per week
- Cost: $75-$150 per month
Twice-Weekly or Daily:
- Best for: Large clinics, hospitals, high volume
- Volume: 50+ pounds per week
- Cost: $300-$1,000+ per month
On-Demand Pickup:
- Best for: Irregular generation, emergencies
- Cost: $150-$300 per pickup (minimum)
Pickup Process:
- Preparation:
- Seal all containers
- Move to pickup location
- Have manifest ready
- Hauler Arrival:
- Verify driver credentials
- Count containers together
- Sign manifest
- Documentation:
- Receive copy of manifest
- Track container barcodes (if applicable)
- File for records
- Follow-Up:
- Receive certificate of destruction (within 30 days)
- Verify treatment facility received waste
- Maintain records for 3 years
Real-World Example:
MedPro Disposal provides weekly pickup for a dental office. Every Tuesday at 10 AM, the driver arrives, scans container barcodes, loads 2-3 sharps containers and 1-2 red bags into the truck, provides digital manifest confirmation, and the office receives a certificate of destruction via email within 5 days.
Step 6: Maintain Compliance Documentation
Proper disposal requires documentation proving waste was handled correctly.
Required Documents:
Manifest (Most Important):
- Generator information (your facility)
- Waste type and quantity
- Hauler information
- Treatment facility destination
- Signatures from generator and transporter
- Date and time of pickup
Certificate of Destruction:
- Confirms waste was treated
- Treatment method used
- Date of treatment
- Treatment facility name and location
- Authorized signature
Training Records:
- Employee names and dates trained
- Topics covered
- Trainer credentials
- Annual refresher training
Incident Reports:
- Spills or exposures
- Container breaches
- Pickup delays
- Any compliance issues
Record Retention:
- Manifests: 3 years minimum (some states require 5)
- Certificates: 3 years minimum
- Training records: Duration of employment + 3 years
- Incident reports: 5 years minimum
Audit Preparation:
Keep organized files with:
- All manifests by date
- All certificates by date
- Training documentation
- Hauler credentials and licenses
- Facility permits
- Waste management plan
Real-World Example:
A medical office maintains a three-ring binder with dividers for: (1) Manifests (chronological), (2) Certificates (chronological), (3) Training records (by employee), (4) Hauler credentials, (5) Facility permits. During an OSHA inspection, they produce all required documentation within 5 minutes.
Special Disposal Situations
Home Healthcare Sharps Disposal:
Options:
- Mail-Back Programs:
- Purchase USPS-approved sharps container with prepaid shipping
- Fill container at home
- Mail back to treatment facility
- Cost: $30-$60 per container (all-inclusive)
- Drop-Off Locations:
- Pharmacies (CVS, Walgreens often accept)
- Hospitals and clinics
- Fire stations (some locations)
- Community collection events
- Cost: Often free
- Pickup Services:
- Schedule home pickup with medical waste company
- Best for high-volume home users
- Cost: $50-$100 per pickup
Never:
- Throw sharps in household trash
- Flush needles down toilet
- Recycle sharps containers
- Reuse sharps containers
Pharmaceutical Waste Disposal:
DEA-Registered Facilities:
- Must maintain controlled substance logs
- Use DEA-authorized disposal methods
- Document all pharmaceutical waste
- May require witnessed destruction
Non-DEA Facilities:
- Use pharmaceutical waste containers
- Incineration required (cannot autoclave)
- Maintain manifests
- Separate chemotherapy waste
Take-Back Programs:
- DEA National Prescription Drug Take-Back Days
- Year-round collection sites
- Law enforcement drop-boxes
- Pharmacy take-back programs
Veterinary Waste Disposal:
Same rules apply:
- Sharps in puncture-resistant containers
- Contaminated materials in red bags
- Animal tissues as pathological waste
- Pharmaceutical waste (especially controlled substances)
Differences:
- Some states have specific veterinary waste regulations
- Animal carcasses may have different disposal requirements
- Zoonotic disease considerations
Cost Breakdown: Complete Disposal Program
Small Medical Office (1-2 Providers):
Monthly Costs:
- Containers: $50-$100
- Weekly pickup service: $150-$250
- Manifests and documentation: Included
- Total: $200-$350 per month
Medium Clinic (5-10 Providers):
Monthly Costs:
- Containers: $150-$300
- Twice-weekly pickup: $400-$700
- Additional services: $50-$100
- Total: $600-$1,100 per month
Large Facility (Hospital, 100+ beds):
Monthly Costs:
- Containers: $500-$1,500
- Daily pickup: $2,000-$5,000
- Pharmaceutical waste: $500-$1,500
- Pathological waste: $300-$1,000
- Total: $3,300-$9,000 per month
Common Mistakes to Avoid
Mistake #1: Overfilling Sharps Containers
- Risk: Needlestick injuries
- Solution: Replace at 3/4 full
Mistake #2: Mixing Waste Types
- Risk: Improper treatment, compliance violations
- Solution: Use separate containers for each waste type
Mistake #3: Storing Waste Too Long
- Risk: Odor, pest attraction, violations
- Solution: Schedule regular pickups
Mistake #4: Using Unlicensed Haulers
- Risk: Illegal dumping, fines, criminal liability
- Solution: Verify all licenses and credentials
Mistake #5: Poor Documentation
- Risk: Cannot prove compliance during audits
- Solution: Maintain organized records for 3+ years
Mistake #6: Inadequate Staff Training
- Risk: Injuries, exposures, violations
- Solution: Train all staff initially and annually
Mistake #7: Improper Container Placement
- Risk: Public access, injuries
- Solution: Place containers in secure, appropriate locations
Frequently Asked Questions
Can I dispose of biomedical waste in regular trash after treatment?
Only if it’s been properly treated (autoclaved, incinerated, or chemically disinfected) by a licensed facility. You cannot treat and dispose on your own unless you have proper permits and equipment.
How often should I schedule pickups?
Depends on volume. Most small offices need weekly pickup. Large facilities need daily or multiple times weekly. Never store waste longer than 7 days at room temperature.
What happens if I accidentally throw biomedical waste in regular trash?
Retrieve it immediately if possible and place in proper container. If waste has left your facility, contact your waste hauler and local health department. Document the incident.
Do I need special training to handle biomedical waste?
Yes. OSHA requires training for anyone who handles biomedical waste. Training must cover waste types, proper handling, container use, and emergency procedures.
Can I reuse sharps containers?
No. Sharps containers are single-use only. Reusing creates needlestick injury risk and is a violation of regulations.
What if my hauler misses a pickup?
Contact them immediately for rescheduling. If waste is approaching storage time limits, request emergency pickup. Document the missed pickup for your records.
Get Compliant Biomedical Waste Disposal with MedPro
Proper biomedical waste disposal doesn’t have to be complicated. MedPro Disposal provides everything you need:

Ben Brenner is a founding partner at MedPro Disposal with over 9 years of hands-on experience in healthcare operations and medical waste management. He works closely with healthcare facilities to ensure OSHA-compliant sharps disposal, regulatory adherence, and safe waste handling practices. Ben contributes industry-backed insights based on real operational experience in the healthcare sector.







